Peer Feedback: Pet Allergy- Vivian To

1. Pathophysiology and its relationship to the symptoms, diagnostic evaluation and treatment in your words  (15 marks) (350 – 400 words) 
Explain in your own words the relationship between the pathophysiology, symptoms, diagnostic evaluation and treatment as explained in the assigned video/podcast.

The pathophysiology of pet allergies, such as Hannah’s allergy to her cat Mr. Meowgi, involves a hypersensitivity type I immune response; in this type of reaction, the immune system mistakenly identifies harmless substances, like pet allergens, as harmful invaders, triggering an immune response.

There are two phases to this- sensitization and effector. When an individual is exposed to Fel D1 (the allergen found in cat saliva and dander), their immune system undergoes sensitization, where immune cells called antigen-presenting cells process the allergen and present it to T-helper cells, which activate the production of IgE antibodies specific to that allergen. These antibodies bind then to mast cells and upon subsequent exposure to the same allergen, the allergen binds to the IgE antibodies on mast cells, triggering the release of various chemicals, such as histamine, interleukins, and leukotrienes. Histamine, in particular, causes the classic symptoms of allergy by dilating blood vessels, increasing mucus production, and leading to inflammation in the airways, eyes, and skin and mast cells are largely abundant in the respiratory tract, which is why, as a result of this immune response, individuals experience symptoms such as sneezing, itchy eyes, nasal congestion, increased mucus production, and scratchy throats, as seen with Hannah. Chronic exposure to the allergen can worsen the symptoms over time due to a positive feedback loop in which more mast cells are recruited to the site, through chemotaxis- perpetuating inflammation and discomfort.

In the podcast, Hannah’s allergy was diagnosed through a skin prick test- which is commonly used for diagnosing allergies. During this test, a small amount of various allergens is introduced under the skin, and if the person is allergic to a substance, a small welt forms at the site of exposure. This test is often followed by a blood test to measure the level of specific IgE antibodies to confirm the diagnosis. This diagnostic process helps identify which allergens are causing the symptoms and can guide treatment.

Unfortunately, the most effective treatment would be to remove Mr. Meowgi from Hannah’s life; however, as she does not want to choose that option, there are pharmaceuticals and medical treatments available. These medications include antihistamines which block histamine receptors to reduce sneezing and itching, corticosteroids to decrease inflammation, and leukotriene modifiers to help with swelling and congestion. Alternatively, environmental changes, like using HEPA filters, frequent cleaning, and washing the cat, help reduce allergen levels in the home. In more severe cases, allergen immunotherapy (AIT) may be recommended. AIT involves gradually exposing the patient to the allergen to build tolerance over time, offering long-term symptom relief. These treatment options are able to provide Hannah with a better quality of life without having to get rid of her beloved Mr Meowgi.

2. Gaps in content (5 marks). (250-300 words)
During your efforts to comprehend the interconnections among various facets of the assigned condition, were there any noticeable gaps in the content or potential additions that could have been included to enhance your understanding of the topic?

This podcast episode was wonderfully done and provides a detailed and insightful explanation of the pathophysiology, symptoms, diagnosis, and treatment of cat allergies. There was just one topic on which I would have liked additional information to enhance my understanding: the lack of exploration on genetic predisposition to allergies.

While the episode explains the immune system’s response to allergens, it doesn’t delve into the fact that some individuals are genetically more likely to develop allergies, including pet allergies. Research shows that allergic conditions often run in families, meaning if a person’s parents have allergies, they are more likely to develop them as well.

I, personally, would have found it beneficial to hear more about how certain genetic factors may increase the risk of allergens more and why, while some individuals may experience mild symptoms, others may suffer more severely. I feel that adding this information would have given a fuller understanding of why some people, like Hannah, are more susceptible to allergies than others, even if they have similar environmental exposures. But I do believe that the podcast was extremely thorough and well made within the time frame given.

3. One teaching-learning strategy that supported or hindered your learning and why (5 marks). (250-300 words) 
Describe one teaching-learning strategy implemented by your peers that supported or hindered your learning. Provide a rationale for your response (5 marks).

One teaching strategy from the podcast that really supported my learning was the use of personal and relatable examples. Hearing a personal story helped make a complex topic, like the immune response to allergens, feel more relatable and easier to understand.

Additionally, the podcast helped bust the myth of hypoallergenic pets—a belief I had always heard but never questioned. Dr. McNabb explained that no cat is truly hypoallergenic, which was eye-opening. She clarified that the allergen Fel D1 is produced by all cats, regardless of breed, and it can still trigger allergic reactions, even in supposedly “hypoallergenic” cats like Hannah’s Sphynx. This myth-busting was really helpful because it challenged a common misconception a lot of people, including myself, have had.

Hearing about Hannah’s struggle with her allergy and her emotional attachment to her cat made the scientific explanation more engaging. It wasn’t just about the science; it also highlighted the real challenges people face when dealing with allergies. I found this connection between the personal and scientific aspects really helpful in making the content more memorable and meaningful.

4. ONE change that you recommend and why (5 marks). (250-300 words) 
If you had an opportunity to make ONE change to the assigned video to further improve its content and/or creativity, what change would you propose? 

One change I would recommend to improve the podcast would be to include visual aids or simple diagrams to help explain some of the more complex scientific concepts. While the podcast does a great job explaining allergies, some ideas, like how mast cells release histamine or how IgE antibodies work, can be tricky to understand without something to look at. Adding a simple graphic or animation could make these ideas easier to follow. For example, a diagram showing how a mast cell interacts with an allergen or how histamine causes symptoms like sneezing could help listeners visualize what’s happening inside the body or visual aids for understanding the steps Dr. McNabb describes, such as the immune system’s response during an allergic reaction. This would make it clearer and more memorable for people who may not have a strong science background and could make the complex science behind allergies more accessible and easier to retain for a wider audience.

While the podcast does a great job of explaining everything in words, some visual learners might find it easier to learn if they could see the process as well as hear it. Visuals would also keep listeners more engaged, especially for those who are more visually oriented or new to the topic. However, I understand that this would require more work, and they already did an excellent job of explaining the details of pet allergies as thoroughly as possible.

5. One example of content integration into your practice (15 marks) (350 – 400 words) 
Provide an example of how you would integrate the information that you learned from the assigned video into your future practice. 

One example of how I would integrate the information learned from the podcast into my future practice as a healthcare professional involves patient education on pet allergies. I would use the information from the podcast to help explain allergies and treatment options to patients in a simple and clear way. From the podcast, I can now create a detailed explanation of the immune response to help educate my patients, especially those newly diagnosed with pet allergies, in a way that is both understandable and relevant to their symptoms.

I would also clarify that no pet is truly hypoallergenic, meaning even breeds that are marketed as allergy-friendly, such as Hannah’s pet sphinx Mr. Meowgi, still produce the allergens that can trigger allergic reactions. This could help patients like Hannah in the podcast better understand why they might still experience allergy symptoms with certain pets, even those said to be hypoallergenic.

I also would be able to review other treatment options with my patients and tailor recommendations based on their individual needs. Pets are part of the family, and there are many who would choose not to give up their pet despite allergies; for those reluctant to rehome their pet, like Hannah, I can give them options on non-pharmacological strategies like improving ventilation, frequent cleaning, and using HEPA filters, in addition to pharmacological treatments like antihistamines, decongestants, corticosteroids to manage symptoms. I would also be able to inform patients about the possibility of allergen immunotherapy, explaining that it might help them build long-term tolerance to allergens, reducing the need for ongoing medication.

With the knowledge from the podcast, I am able to advocate for people with pet allergies to keep living with their beloved pets with the proper interventions in place. By integrating this information into my practice, I can help patients better understand their condition, manage their pet allergy symptoms, and make informed decisions about treatment options.